N-Iodosuccinimide → 3-Iodo-7-methyl-2-pyridin-4-ylimidazo[1,2-a]pyridine
반응식
[CH3:1][C:2]1[CH:7]=[CH:6][N:5]2[CH:8]=[C:9]([C:11]3[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=3)[N:10]=[C:4]2[CH:3]=1.[I:17]N1C(=O)CCC1=O>C(#N)C>[I:17][C:8]1[N:5]2[CH:6]=[CH:7][C:2]([CH3:1])=[CH:3][C:4]2=[N:10][C:9]=1[C:11]1[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=1참가 물질
4
실험 절차
A mixture of 7-methyl-2-pyridin-4-ylimidazo[1,2-a]pyridine (6.52 g, 31.1 mmol), N-iodosuccinimide (7.0 g, 31.1 mmol) and ACN (180 ml) is stirred at RT for 17 h. The precipitate is collected, washed with ACN and dried. Yield: 4.4 g (42%). HPLC-MS: M+H=336; tR=1.55 min (*Method—3).
후처리
- customThe precipitate is collected
- washwashed with ACN
- customdried
출처 및 근거
- ORD 기록
- ord-02b0edd80f884fd48c811471739774dc
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859541B2
반응 노트
불러오는 중…