Hydrazine hydrate (1:1) → HCID 23153686, 화합물

HRID 535495노트

반응식

HRID 535495 반응식
[CH3:1][O:2][C:3]1[CH:21]=[CH:20][C:6]([C:7]([C:9]2[CH:19]=[CH:18][CH:17]=[CH:16][C:10]=2[C:11](OCC)=[O:12])=O)=[CH:5][N:4]=1.O.[NH2:23][NH2:24]>C(O)C>[CH3:1][O:2][C:3]1[N:4]=[CH:5][C:6]([C:7]2[C:9]3[C:10](=[CH:16][CH:17]=[CH:18][CH:19]=3)[C:11](=[O:12])[NH:24][N:23]=2)=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 70976014HCID 70976014, 화합물

생성물 1

HCID 23153686HCID 23153686, 화합물

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of ethyl 2-(6-methoxynicotinoyl)benzoate (0.496 g, 1.74 mmol) and hydrazine hydrate (0.39 mL, 6.9 mmol) in ethanol (6 mL) was stirred at 80° C. for 2 hours, concentrated, and azeotroped with PhMe to give crude 4-(6-methoxypyridin-3-yl)phthalazin-1(2H)-one, which was used without purification.

후처리

  1. concentrationconcentrated
  2. customazeotroped with PhMe

출처 및 근거

ORD 기록
ord-d5adcc662f5d4aa0b7086a4cc4f30acc
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859549B2

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