Mesitylacetic acid → N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(2,4,6-trimethylphenyl)acetamide

참여 물질

역할	이름	HCID	투입량
반응물	Mesitylacetic acid	HCID 78123	—
반응물	2-amino-4-morpholinophthalazin-1(2H)-one	HCID 70976104	—
생성물	N-[4-(morpholin-4-yl)-1-oxophthalazin-2(1H)-yl]-2-(2,4,6-trimethylphenyl)acetamide	HCID 70976029	—

반응 단계

The product of Example 1B and 2-(2,4,6-trimethylphenyl)acetic acid were treated using a method similar to that described in Example 111 to give the title compound. 1H NMR (500 MHz, DMSO-d6/Deuterium Oxide) δ ppm 8.30 (d, J=7.3 Hz, 1H), 8.02 (d, J=8.0 Hz, 1H), 7.96-8.00 (m, 1H), 7.88-7.92 (m, 1H), 6.84-6.85 (bs, 2H), 3.77-3.85 (m, 4H), 3.66 (s, 2H), 3.08-3.13 (m, 4H), 2.31 (s, 6H), 2.21 (s, 3H); MS (ESI+) M/Z 407 (M+H)+.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08859549B2
출처 데이터셋	uspto-grants-2014_10
ORD ID	ord-fcceb814cb684bf2979726fc7da9ff01
출처 메모	uspto-grants-2014_10