Azetidine → Azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone

HRID 535661

반응식

HRID 535661 반응식
C([O:3][C:4]([C:6]1[O:7][C:8]2[C:14]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[CH2:17][CH2:16]3)=[CH:13][CH:12]=[CH:11][C:9]=2[CH:10]=1)=O)C.[NH:28]1[CH2:31][CH2:30][CH2:29]1>>[N:28]1([C:4]([C:6]2[O:7][C:8]3[C:14]([N:15]4[CH2:20][CH2:19][N:18]([CH2:21][C:22]5[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=5)[CH2:17][CH2:16]4)=[CH:13][CH:12]=[CH:11][C:9]=3[CH:10]=2)=[O:3])[CH2:31][CH2:30][CH2:29]1

참가 물질

3

반응물 2

HCID 10422AzetidineHCID 596367457-(4-Benzyl-piperazin-1-yl)-benzofuran-2-carboxylic acid ethyl ester

생성물 1

HCID 59636710Azetidin-1-yl(7-(4-benzylpiperazin-1-yl)benzofuran-2-yl)methanone

실험 절차

The compound was prepared according to the procedure disclosed in Example 39c starting from ethyl 7-(4-benzylpiperazin-1-yl)benzofuran-2-carboxylate (1.0 g, 2.74 mmol) (Example 39b) and azetidine (0.20 mL, 3.02 mmol). Yield: 0.52 g (51%).

후처리

  1. customThe compound was prepared

출처 및 근거

ORD 기록
ord-7d7c01000a9249078b6ff33f1e2a68c3
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859534B2

연결된 노트

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