Hydrochloric Acid → 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one

HRID 535990노트

반응식

HRID 535990 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:16](COCC[Si](C)(C)C)[C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1.Cl>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:16][C:15]3[C:14](=[O:25])[N:13]([CH2:26][CH2:27][CH3:28])[CH:12]=[N:11][C:10]=3[N:9]=2)=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 1363910238-(4-Hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one

생성물 1

HCID 1363910248-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one수율 95%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
85 °C

실험 절차

A mixture of 8-(4-hydroxy-phenyl)-1-propyl-7-(2-trimethylsilanyl-ethoxymethyl)-1,7-dihydro-purin-6-one (0.03 g, 0.075 mmol), 2N HCl (1 ml), ethanol (2 ml) was heated at 85° C. for 2 hours. The mixture was cooled and the solvent was evaporated. The residue was washed with n-pentane to obtain 8-(4-Hydroxy-phenyl)-1-propyl-1,7-dihydro-purin-6-one (0.019 g, 95%) as a yellow solid.

후처리

  1. temperatureThe mixture was cooled
  2. customthe solvent was evaporated
  3. washThe residue was washed with n-pentane

출처 및 근거

ORD 기록
ord-cbe06aee8ca24e15a7ccae9ef4376537
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859566B2

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