반응식
Cl.C(O[C:5]([C:7]1[NH:8][CH:9]=[CH:10][C:11]=1[NH2:12])=[O:6])C.[F:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH:23]=O.[BH3-]C#N.[Na+].CCN(CC)CC.C([N:44]=[C:45]=[S:46])(=O)C1C=CC=CC=1>CO>[F:13][C:14]1[CH:15]=[C:16]2[C:20](=[CH:21][CH:22]=1)[NH:19][CH:18]=[C:17]2[CH2:23][N:12]1[C:11]2[CH:10]=[CH:9][NH:8][C:7]=2[C:5](=[O:6])[NH:44][C:45]1=[S:46]참가 물질
반응물 5
생성물 1
시약·촉매·용매 1
실험 절차
3-Amino-1H-pyrrole-2-carboxylic acid ethyl ester hydrochloride (0.10 g, 0.52 mmol) was dissolved in methanol (4 mL) and 5-fluoro-1H-indole-3-carboxaldehyde (0.10 g, 0.63 mmol), NaCNBH3 (0.033 g, 0.52 mmol) and Et3N (0.073 g, 0.52 mmol) were added. The resulting mixture was stirred at r.t. overnight. Additional NaCNBH3 (0.01 g) was added and the mixture was heated at 50° C. for 5 h. The reaction mixture was cooled to r.t. and concentrated in vacuo. The crude intermediate was dissolved in CH2Cl2 (3 mL) and methanol (1 mL). Benzoyl isothiocyanate (0.078 mL, 0.58 mmol) was added and after stirring at r.t. for 1 h the mixture was concentrated in vacuo. The residue was dissolved in ammonia (7N in methanol, 3 mL) and heated at 80° C. for 2 h. The solvent was removed in vacuo and after purification by preparative HPLC, the title compound (0.035 g, 21%) was obtained as a solid.
후처리
- temperaturethe mixture was heated at 50° C. for 5 h
- temperatureThe reaction mixture was cooled to r.t.
- concentrationconcentrated in vacuo
- dissolutionThe crude intermediate was dissolved in CH2Cl2 (3 mL)
- stirringafter stirring at r.t. for 1 h the mixture
- concentrationwas concentrated in vacuo
- dissolutionThe residue was dissolved in ammonia (7N in methanol, 3 mL)
- temperatureheated at 80° C. for 2 h
- customThe solvent was removed in vacuo
- customafter purification by preparative HPLC
출처 및 근거
- ORD 기록
- ord-a04e86668dd74bb18d635926ec5be031
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859568B2
연결된 노트
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