Propargyl bromide → 1-(Prop-2-ynyloxy)-2-(trifluoromethoxy)benzene
반응식
[F:1][C:2]([F:12])([F:11])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[OH:10].C(=O)([O-])[O-].[K+].[K+].[CH2:19](Br)[C:20]#[CH:21]>C(#N)C.O>[CH2:21]([O:10][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[O:3][C:2]([F:11])([F:12])[F:1])[C:20]#[CH:19]참가 물질
6
실험 절차
To a solution of 2-trifluoromethoxyphenol (10.0 g, 56.1 mmol) in acetonitrile (120 mL) was added potassium carbonate (9.31 g, 67.4 mmol) and propargyl bromide (80% in toluene, 10.0 g, 7.70 mL, 67.4 mmol). The reaction mixture was stirred at ambient temperature for seven days, then diluted with water (150 mL) and extracted with diethyl ether (300 mL). The organic layer was separated and concentrated to obtain the title compound (13.05 g) which was used without further purification in the next step.
후처리
- extractionextracted with diethyl ether (300 mL)
- customThe organic layer was separated
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-e628bdc37ccd441c99c7eee47e218df7
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859584B2
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