Hydrochloric Acid → 5-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

HRID 536636노트

반응식

HRID 536636 반응식
[CH3:1][O:2][C:3](=[O:18])[CH2:4][CH:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([O:14][CH3:15])[CH:12]=2)[C:7](=[N:16]O)[CH2:6]1.[ClH:19]>[Pd].CO>[Cl-:19].[CH3:15][O:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[CH:7]([NH3+:16])[CH2:6][CH:5]2[CH2:4][C:3]([O:2][CH3:1])=[O:18]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86650493(3-Hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester

생성물 1

HCID 866562075-Methoxy-3-methoxycarbonylmethyl-indan-1-yl-ammonium chloride

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 10% palladium on carbon (3.0 g), (3-hydroxyimino-6-methoxy-indan-1-yl)-acetic acid methyl ester (12.5 g), and concentrated hydrochloric acid (4.7 mL) in methanol (150 mL) is stirred under hydrogen atmosphere at room temperature overnight. The mixture is filtered and the filtrate is concentrated under reduced pressure. The residue is azeotropically dried using toluene and washed with diisopropylether to give the product as a white solid after drying at 50° C.

후처리

  1. filtrationThe mixture is filtered
  2. concentrationthe filtrate is concentrated under reduced pressure
  3. customThe residue is azeotropically dried
  4. washwashed with diisopropylether

출처 및 근거

ORD 기록
ord-8c65e05a468e4c91a5f8a0a309f50f68
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859580B2

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