Iodine → 2-[2-(Diethylamino)ethyl]-6-phenyl-isothiazolo[5,4-d]pyrimidin-3(2H)-one

HRID 53684

반응식

HRID 53684 반응식
[CH2:1]([N:3]([CH2:22][CH3:23])[CH2:4][CH2:5][NH:6][C:7]([C:9]1[C:10]([SH:21])=[N:11][C:12]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[N:13][CH:14]=1)=[O:8])[CH3:2].II>>[CH2:22]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][N:6]1[C:7](=[O:8])[C:9]2[C:10](=[N:11][C:12]([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)=[N:13][CH:14]=2)[S:21]1)[CH3:23]

참가 물질

3

반응물 2

HCID 807IodineHCID 178418472HCID 178418472, 화합물

생성물 1

HCID 99055032-[2-(Diethylamino)ethyl]-6-phenyl-isothiazolo[5,4-d]pyrimidin-3(2H)-one수율 68.5%

실험 절차

Using the procedure of Example 20, 3.3 g (0.01 mol) of 4-mercapto-2-phenyl-pyrimidine-5-carboxylic acid (2-diethylamino-ethyl)-amide (from Preparation 36) and 2.54 g (0.01 mol) of iodine were reacted to give 2.25 g of the title compound after recrystallization from isopropanol, mp 106°-107° C.

후처리

  1. customwere reacted

출처 및 근거

ORD 기록
ord-1d1e11fe5f674c7fb54b5254332ae6fe
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05620997

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