Sodium Carbonate → Ethyl 5-bromofuran-3-carboxylate
반응식
[O:1]1[CH:5]=[CH:4][C:3]([C:6]([O:8][CH2:9][CH3:10])=[O:7])=[CH:2]1.[Br:11]Br.C([O-])([O-])=O.[Na+].[Na+]>C(Cl)(Cl)Cl>[Br:11][C:5]1[O:1][CH:2]=[C:3]([C:6]([O:8][CH2:9][CH3:10])=[O:7])[CH:4]=1참가 물질
5
실험 절차
To a solution of ethyl 3-furoate (50.0 g, 360 mmol) in chloroform (380 mL) was added bromine (56.0 g, 360 mmol) in chloroform. The reaction mixture was allowed to stir at rt overnight and then poured into 10% aqueous Na2CO3. The mixture was extracted with DCM. The organic solutions were combined and washed with water until pH=7. The organic solution was concentrated and then distilled to give ethyl 5-bromo-3-furoate (42 g, 40%).
후처리
- extractionThe mixture was extracted with DCM
- washwashed with water until pH=7
- concentrationThe organic solution was concentrated
- distillationdistilled
출처 및 근거
- ORD 기록
- ord-7406ec14cb494712806516432f970ee3
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08859768B2
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