N-bromobutanimide → Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate

HRID 537062노트

반응식

HRID 537062 반응식
[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[O:15][CH:14]=[C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:12]=2)[C:8]([CH3:21])=[CH:7][N:6]=1)(=[O:3])[CH3:2].C1C(=O)N([Br:29])C(=O)C1>CN(C=O)C>[C:1]([NH:4][C:5]1[CH:10]=[C:9]([C:11]2[O:15][C:14]([Br:29])=[C:13]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH:12]=2)[C:8]([CH3:21])=[CH:7][N:6]=1)(=[O:3])[CH3:2]

참가 물질

4

반응물 2

HCID 67184N-bromobutanimideHCID 66748598Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-3-furoate

생성물 1

HCID 66748591Ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate수율 77.9%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

To a solution of ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-3-furoate (20.0 g, 69.9 mmol) in DMF (90 mL) was added NBS (29.6 g, 168.1 mmol). The reaction mixture was allowed to stir at 80° C. overnight and then concentrated. The residue was washed with EtOH and filtered to give ethyl 5-(2-acetamido-5-methylpyridin-4-yl)-2-bromo-3-furoate (20 g, 60%).

후처리

  1. concentrationconcentrated
  2. washThe residue was washed with EtOH
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-7f6fd8cc03f944ee8a3915adc15f1eda
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859768B2

반응 노트

불러오는 중…