Potassium Carbonate → Methyl 3-(cyclopropylmethoxy)-4-nitrobenzoate

HRID 537233노트

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HRID 537233 반응식
[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([OH:13])[CH:5]=1.C([O-])([O-])=O.[K+].[K+].[CH:21]1([CH2:24]Br)[CH2:23][CH2:22]1>CN(C=O)C.O>[CH3:1][O:2][C:3](=[O:14])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[C:6]([O:13][CH2:24][CH:21]2[CH2:23][CH2:22]2)[CH:5]=1

참가 물질

6

반응물 3

HCID 11430Potassium CarbonateHCID 81503BromomethylcyclopropaneHCID 294866Methyl 3-hydroxy-4-nitrobenzoate

생성물 1

HCID 59443763Methyl 3-(cyclopropylmethoxy)-4-nitrobenzoate

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

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온도
50 °C

실험 절차

3-Hydroxy-4-nitro-benzoic acid methyl ester (10.5 g) was dissolved in dry DMF (150 ml) under N2 atmosphere. K2CO3 (24.3 g), K1 (2.6 g) and cyclopropylmethylbromide (10.3 ml) were added and the mixture was stirred at 50° C. for 6 hours. The reaction mixture was diluted with water (300 ml) and extracted with Et2O (2×200 ml); the combined organic layers were dried over Na2SO4 and the solvent was removed by evaporation to yield 12.7 g of the desired intermediate.

후처리

  1. extractionextracted with Et2O (2×200 ml)
  2. dry with materialthe combined organic layers were dried over Na2SO4
  3. customthe solvent was removed by evaporation

출처 및 근거

ORD 기록
ord-d5a3b22968ef4b7dbe6b9f8b8ae67c82
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08859778B2

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