Acetic Anhydride → 3',5'-Bis(trifluoromethyl)acetanilide

반응식

[F:1][C:2]([F:15])([F:14])[C:3]1[CH:4]=[C:5]([CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[CH:9]=1)[NH2:6].[C:16](OC(=O)C)(=[O:18])[CH3:17]>>[C:16]([NH:6][C:5]1[CH:4]=[C:3]([C:2]([F:14])([F:15])[F:1])[CH:9]=[C:8]([C:10]([F:11])([F:12])[F:13])[CH:7]=1)(=[O:18])[CH3:17]

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 9480Benzenamine, 3,5-bis(trifluoromethyl)-

생성물 1

HCID 7236003',5'-Bis(trifluoromethyl)acetanilide수율 98%

실험 절차

A solution of 3,5-bis(trifluoromethyl)aniline (1.28 g, 5 mmol, Aldrich) in acetic anhydride (5 mL) was stirred at room temperature for 12 h, then all of the solvent was removed to give 1.479 g (98%) of 1-acetamido-3,5-bis(trifluoromethyl)benzene as white needles. 1H NMR (CDCl3): δ 2.229 (s, 3H); 7.589 (s, 1H); 8.048 (s, 2H).

후처리

customall of the solvent was removed

출처 및 근거

ORD 기록: ord-caf773cb9d654064bdbcdf75a7a27d40
출처 데이터셋: uspto-grants-1997_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05620979

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