Water → 4-Trifluoromethyl-1,2-phenylenediamine
반응식
[N+:1]([C:4]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:5]=1[NH2:6])([O-])=O.Cl[Sn]Cl.O.C([O-])(O)=O.[Na+]>C(O)C>[F:12][C:11]([F:13])([F:14])[C:9]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4]([NH2:1])[CH:10]=1참가 물질
6
실험 절차
A solution of 2-nitro-4-trifluoromethylaniline (5.000 g, 24.26 mmol, Aldrich, used as received) and SnCl2.2 H2O (20.00 g, 88.64 mmol, Aldrich, used as received) in absolute ethanol (50 mL) was refluxed for 45 min. It was then poured into ice (85 g) and basified with 10% aq. NaHCO3 (250 mL). The resulting suspension was extracted with ethyl acetate (400 mL). The ethyl acetate extract was dried over Na2SO4 and evaporated to give 4.14 g (87%) of pure 4-trifluoromethyl-1,2-phenylenediamine as a red powder.
후처리
- extractionThe resulting suspension was extracted with ethyl acetate (400 mL)
- extractionThe ethyl acetate extract
- dry with materialwas dried over Na2SO4
- customevaporated
출처 및 근거
- ORD 기록
- ord-87709eac85a547ac97c7cbd71cbdd542
- 출처 데이터셋
- uspto-grants-1997_04
- 특허 번호
- US05620979
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