Lithium Hydroxide → 7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538222노트

반응식

HRID 538222 반응식
[OH-:1].[Li+].[Cl:3][C:4]1[N:9]=[C:8](SC)[N:7]2[CH:12]=[C:13]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:6]2[CH:5]=1>O.C1COCC1.C(Cl)Cl>[Cl:3][C:4]1[NH:9][C:8](=[O:1])[N:7]2[CH:12]=[C:13]([CH2:15][O:16][C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[N:14]=[C:6]2[CH:5]=1

참가 물질

6

반응물 2

HCID 3939Lithium HydroxideHCID 866964987-Chloro-5-methylsulfanyl-2-phenoxymethyl-imidazo[1,2-c]pyrimidine

생성물 1

HCID 1363786247-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one수율 98.2%

시약·촉매·용매 3

HCID 962Water용매HCID 6344Dichloromethane용매HCID 8028Tetrahydrofuran용매

반응 조건

온도
50 °C

실험 절차

A solution of lithium hydroxide (66 mg, 2.75 mmol) in H2O (10 mL) was added to a solution of 7-chloro-5-methylsulfanyl-2-phenoxymethyl-imidazo[1,2-c]pyrimidine (0.70 g, 2.29 mmol) in THF (10 mL). The mixture was stirred at 50° C. for 4 hours and then diluted with DCM. The organic layer was separated, dried (Na2SO4), filtered and the solvents evaporated in vacuo to yield 7-chloro-2-phenoxymethyl-6H-imidazo[1,2-c]pyrimidin-5-one (0.62 g, 98% yield) as a white solid that was used in the next step without further purification.

후처리

  1. customThe organic layer was separated
  2. dry with materialdried (Na2SO4)
  3. filtrationfiltered
  4. customthe solvents evaporated in vacuo

출처 및 근거

ORD 기록
ord-8e0e01159a9e4dddb29aa7743b138b56
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865725B2

반응 노트

불러오는 중…