1,3-Dichloroacetone → 2-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one

HRID 538236노트

반응식

HRID 538236 반응식
NC1C=CN(CC2CC2)C(=O)N=1.ClCC(CCl)=O.[Cl:19][CH2:20][C:21]1[N:22]=[C:23]2[CH:28]=[CH:27][N:26]([C:29]3[CH:34]=[CH:33][C:32](F)=CC=3)[C:25](=[O:36])[N:24]2[CH:37]=1>>[Cl:19][CH2:20][C:21]1[N:22]=[C:23]2[CH:28]=[CH:27][N:26]([CH2:29][CH:34]3[CH2:33][CH2:32]3)[C:25](=[O:36])[N:24]2[CH:37]=1

참가 물질

4

반응물 3

HCID 107931,3-DichloroacetoneHCID 214443201-CyclopropylmethylcytosineHCID 682908442-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one

생성물 1

HCID 682906012-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one

실험 절차

2-Chloromethyl-6-cyclopropylmethyl-6H-imidazo[1,2-c]pyrimidin-5-one was prepared from 4-amino-1-cyclopropylmethyl-1H-pyrimidin-2-one and 1,3-dichloroacetone using the methods described above for the preparation of 2-chloromethyl-6-(4-fluoro-phenyl)-6H-imidazo[1,2-c]pyrimidin-5-one.

출처 및 근거

ORD 기록
ord-16e8acce3ba246edbda2175d886d0296
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865725B2

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