Hydrochloric Acid → 2-(Pyrimidin-4-yl)benzoic acid hydrochloride

HRID 538460노트

반응식

HRID 538460 반응식
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([O:11]C)=[O:10])=[N:3][CH:2]=1.[ClH:17]>C(O)(=O)C>[ClH:17].[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:16]=[CH:15][CH:14]=[CH:13][C:8]=2[C:9]([OH:11])=[O:10])=[N:3][CH:2]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 86680852Methyl 2-(pyrimidin-4-yl)benzoate

생성물 1

HCID 866808532-(Pyrimidin-4-yl)benzoic acid hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of methyl 2-(pyrimidin-4-yl)benzoate (0.49 g), acetic acid (2.0 mL) and 6 N hydrochloric acid (10 mL) was heated under reflux for 5 hr. The solvent was evaporated under reduced pressure, and the obtained residue was washed with ethyl acetate to give the title compound (0.45 g).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 5 hr
  3. customThe solvent was evaporated under reduced pressure
  4. washthe obtained residue was washed with ethyl acetate

출처 및 근거

ORD 기록
ord-93ddf8e9b2694f25803e12a7d3ebd9ae
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865717B2

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