Hydrochloric Acid → 4-Fluoro-2-(pyridin-4-yl)benzoic acid hydrochloride
반응식
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([C:12]2[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=2)[CH:3]=1.[ClH:18]>>[ClH:18].[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)[CH:3]=1참가 물질
3
반응 조건
- 온도
- 90 °C
실험 절차
A mixture of methyl 4-fluoro-2-(pyridin-4-yl)benzoate (0.88 g) and 6 N hydrochloric acid (13 mL) was stirred at 90° C. for 18 hr. The solvent was evaporated under reduced pressure to give the title compound (0.96 g).
후처리
- customThe solvent was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-ef6b15d2229d43bdb124746268372540
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08865717B2
반응 노트
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