1,3-Dichloroacetone → 4-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-oxazole

HRID 538565

반응식

HRID 538565 반응식
[Cl:1][CH2:2][C:3]([CH2:5]Cl)=O.[CH3:7][O:8][C:9]1[CH:17]=[CH:16][C:12]([C:13]([NH2:15])=[O:14])=[CH:11][CH:10]=1>C1(C)C=CC=CC=1>[Cl:1][CH2:2][C:3]1[N:15]=[C:13]([C:12]2[CH:16]=[CH:17][C:9]([O:8][CH3:7])=[CH:10][CH:11]=2)[O:14][CH:5]=1

참가 물질

4

반응물 2

HCID 107931,3-DichloroacetoneHCID 769594-Methoxybenzamide

생성물 1

HCID 199587944-(Chloromethyl)-2-(4-methoxyphenyl)-1,3-oxazole수율 87.1%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
120 °C

실험 절차

To a solution of 1,3 dichloroacetone (0.504 g, 3.90 mmol) in toluene (5 ml) was added 4-methoxy benzamide (0.30 g, 1.90 mmol). The reaction mixture was heated at 120° C. for 1 h. After the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure and the residue was purified over silica gel (230-400 M, 15% EtOAc-Hexane) to get the desired product (0.37 g, 83%).

후처리

  1. customAfter the completion of the reaction mixture (TLC monitoring), the reaction mixture was evaporated to dryness under reduced pressure
  2. customthe residue was purified over silica gel (230-400 M, 15% EtOAc-Hexane)

출처 및 근거

ORD 기록
ord-251913861c1c40c8b1d5c54fd78d2d74
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08865736B2

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