Iodoethane → 3-Bromo-1-ethyl-2(1H)-pyridinone
반응식
[Br:1][C:2]1[C:3]([OH:8])=[N:4][CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[Cs+].[Cs+].[CH2:15](I)[CH3:16]>CN(C=O)C>[Br:1][C:2]1[C:3](=[O:8])[N:4]([CH2:15][CH3:16])[CH:5]=[CH:6][CH:7]=1참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
A mixture of 3-bromopyridin-2-ol (1.0 g, 5.75 mmol) in DMF (6 mL) was treated with cesium carbonate (1.87 g, 5.75 mmol) and ethyl iodide (1.38 mL, 17.2 mmol). The mixture was heated at 80° C. for 4 hours. The solvent was concentrated and the residue taken in EtOAc, washed with brine, dried (phase separator silicone treated filter paper), concentrated and purified on silica gel (1:2 hexane/ether) to provide 3-bromo-1-ethylpyridin-2(1H)-one (0.905 g, 78% yield) as a yellow oil.
후처리
- concentrationThe solvent was concentrated
- washwashed with brine
- customdried
- addition(phase separator silicone treated filter paper)
- concentrationconcentrated
- custompurified on silica gel (1:2 hexane/ether)
출처 및 근거
- ORD 기록
- ord-6530cf86fe2b4a1f8d0ad66752c60f8d
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08865726B2
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