Benzylamine → N-benzylmethanesulfonamide

HRID 539600

반응식

HRID 539600 반응식
[CH2:1]([NH2:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:9][S:10](Cl)(=[O:12])=[O:11]>C(Cl)Cl.O>[CH2:1]([NH:8][S:10]([CH3:9])(=[O:12])=[O:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 7504BenzylamineHCID 31297Methanesulfonyl chloride2회

생성물 1

HCID 235490N-benzylmethanesulfonamide

시약·촉매·용매 2

HCID 962Water용매HCID 6344Dichloromethane용매

실험 절차

18.27 g of benzylamine were dissolved in 100 ml of methylene chloride and, while cooling with ice, 6.00 ml of methanesulfonyl chloride were very slowly added dropwise. On completion of addition of the methanesulfonyl chloride, the reaction solution was diluted with 100 ml of water, and the aqueous phase was extracted again with 50 ml of methylene chloride. The combined organic phases were washed with 1 N aqueous hydrochloric acid, dried over MgSO4 and concentrated by rotary evaporation. This gave the product (14.40 g) with a molecular weight of 185.3 g/mol (C8H11NO2S).

후처리

  1. additionwere very slowly added dropwise
  2. extractionthe aqueous phase was extracted again with 50 ml of methylene chloride
  3. washThe combined organic phases were washed with 1 N aqueous hydrochloric acid
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated by rotary evaporation

출처 및 근거

ORD 기록
ord-54820aa9a05248b7923d1f9ef6cee000
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871758B2

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