Potassium Carbonate → N-(5-(6-(4-cyano-2-(trifluoromethyl)phenyl)imidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

반응식

[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]3[CH:15]=[CH:14][C:13](B(O)O)=[N:12][N:11]3[CH:19]=2)=[CH:4][C:3]=1[NH:20][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23].Br[C:28]1[CH:35]=[CH:34][C:31]([C:32]#[N:33])=[CH:30][C:29]=1[C:36]([F:39])([F:38])[F:37].C([O-])([O-])=O.[K+].[K+].C1(P(C2CCCCC2)C2C=CC=CC=2C2C(OC)=CC=CC=2OC)CCCCC1>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(O)(C)C.O>[C:32]([C:31]1[CH:34]=[CH:35][C:28]([C:13]2[CH:14]=[CH:15][C:10]3[N:11]([CH:19]=[C:8]([C:5]4[CH:6]=[CH:7][C:2]([CH3:1])=[C:3]([NH:20][C:21](=[O:26])[C:22]([CH3:25])([CH3:24])[CH3:23])[CH:4]=4)[N:9]=3)[N:12]=2)=[C:29]([C:36]([F:37])([F:38])[F:39])[CH:30]=1)#[N:33]