1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one → 1,6-Naphthyridine-2,4(1H,3H)-dione

HRID 539943

반응식

HRID 539943 반응식
C([N:8]1[C:17]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:11]([OH:18])=[CH:10][C:9]1=[O:19])C1C=CC=CC=1>FC(F)(F)S(O)(=O)=O>[NH:8]1[C:17]2[C:12](=[CH:13][N:14]=[CH:15][CH:16]=2)[C:11](=[O:18])[CH2:10][C:9]1=[O:19]

참가 물질

3

반응물 1

HCID 712553201-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one

생성물 1

HCID 691080981,6-Naphthyridine-2,4(1H,3H)-dione

시약·촉매·용매 1

HCID 62406Trifluoromethanesulfonic acid용매

반응 조건

온도
120 °C

실험 절차

A mixture of 1-benzyl-4-hydroxy-1,6-naphthyridin-2(1H)-one (21 g, 0.08 mol) and trifluoromethanesulfonic acid (100 mL) was heated with stirring at 120° C. overnight. The reaction mixture was used for the next step directly.

후처리

  1. temperaturewas heated

출처 및 근거

ORD 기록
ord-6eec20b939d6490a8d658d34fc4f323a
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871756B2

연결된 노트

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