Benzylamine → 3-(Benzylamino)oxetan-3-acetonitrile

반응식

[O:1]1[CH2:4][C:3](=[CH:5][C:6]#[N:7])[CH2:2]1.[C:8]1([CH2:14][NH2:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[CH2:14]([NH:15][C:3]1([CH2:5][C:6]#[N:7])[CH2:4][O:1][CH2:2]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 7504Benzylamine

HCID 533465742-(3-Oxetanylidene)acetonitrile

생성물 1

HCID 712544323-(Benzylamino)oxetan-3-acetonitrile수율 81.7%

반응 조건

온도: 60 °C

실험 절차

A mixture of oxetan-3-ylidene-acetonitrile (950 mg, 10 mmol) and phenylmethanamine (1.31 ml, 12 mmol) was heated with stirring at 60° C. for 5 hours under nitrogen. The mixture was concentrated in vacuo. The residue was purified by flash column (eluting with 0-50% ethyl acetate in hexane) to afford 1.65 g of 3-(benzylamino)oxetan-3-acetonitrile as a colorless oil (yield was 81.7%).

후처리

temperaturewas heated
concentrationThe mixture was concentrated in vacuo
customThe residue was purified by flash column (eluting with 0-50% ethyl acetate in hexane)

출처 및 근거

ORD 기록: ord-f6fb773555f448fcb701bb36f3d522de
출처 데이터셋: uspto-grants-2014_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08871756B2

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