1-Naphthol → Carbaryl

HRID 54029

반응식

HRID 54029 반응식
[C:1]1([OH:11])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH3:12][NH:13][C:14](=S)[OH:15].[Na]>C1C=CC=CC=1>[CH3:12][NH:13][C:14](=[O:15])[O:11][C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 70051-NaphtholHCID 5360545SodiumHCID 178486072HCID 178486072, 화합물

생성물 1

HCID 6129Carbaryl

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

To a solution of 1-naphthol (1.44 g, 0.01 mole) and S-methyl ester of N-methylcarbamothioic acid (1.575 g, 0.015 mole) in benzene (6 ml) there was added sodium (0.15 g) and the mixture was refluxed for 20 hrs. The reaction mixture was cooled and washed with water and a cold 5% NaOH solution followed by water and brine and then dried. The removal of solvent afforded the solid which was further purified by crystallization to furnish 1-naphthyl N-methylcarbamate of the formula VII, m.p. 140°-141° C., IR: 3305 (N--H), 1715 (--COO--), 1600, 1540, 770 (aromatic): PMR (CdCl3, 90 MHz), 2.86 (3H, d, J=1Hz, NH--CH3, 5.14 (1H, hr. s, N--H) and 7.17 to 8 (7H, m, aromatic).

후처리

  1. temperaturethe mixture was refluxed for 20 hrs
  2. temperatureThe reaction mixture was cooled
  3. washwashed with water
  4. customdried
  5. customThe removal of solvent
  6. customafforded the solid which
  7. customwas further purified by crystallization

출처 및 근거

ORD 기록
ord-25de297a1e344fab8901bea4e99c3aad
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05621132

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