Hydrochloric Acid → HCID 71255323, 화합물

HRID 540342노트

반응식

HRID 540342 반응식
CC1(C)[N:6](C(OC(C)(C)C)=O)[C@@H:5]([CH2:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[C:18]([N:26]3[CH2:32][CH2:31][CH2:30][C:29]4[CH:33]=[CH:34][CH:35]=[CH:36][C:28]=4[CH2:27]3)[CH:17]=2)[CH2:4][O:3]1.Cl.C(=O)([O-])[O-].[Na+].[Na+]>C(OCC)(=O)C>[NH2:6][C@@H:5]([CH2:14][CH2:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[N:19]=[C:18]([N:26]2[CH2:32][CH2:31][CH2:30][C:29]3[CH:33]=[CH:34][CH:35]=[CH:36][C:28]=3[CH2:27]2)[CH:17]=1)[CH2:4][OH:3]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 86691447HCID 86691447, 화합물

생성물 1

HCID 71255323HCID 71255323, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To the solution of tert-butyl (4S)-2,2-dimethyl-4-{2-[2-(1,3,4,5-tetrahydro-2H-2-benzazepin-2-yl)quinolin-4-yl]ethyl}-1,3-oxazolidine-3-carboxylate (340 mg, 0.68 mmol) in ethyl acetate was introduced hydrochloric acid gas for 30 minutes. After being stirred at room temperature overnight, the reaction was poured into ice-water then neutralized with saturated sodium carbonate. The organic layer was separated, dried over sodium sulfate, and then concentrated in vacuo to give the product. It was used in next step without further purification. MS obsd. (ESI+) [(M+H)+] 362.

후처리

  1. customThe organic layer was separated
  2. dry with materialdried over sodium sulfate
  3. concentrationconcentrated in vacuo
  4. customto give the product
  5. customIt was used in next step without further purification

출처 및 근거

ORD 기록
ord-43a9d792fb8b4495b6c9566e355f4086
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871756B2

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