Sodium Hydroxide → HCID 178433263, 화합물
반응식
[CH3:1][C:2]1[N:6]=[CH:5][NH:4][C:3]=1[CH:7]=[CH:8][C:9]([Cl:11])=[O:10].[OH-].[Na+].[H][H]>[Pd]>[CH3:1][C:2]1[N:6]=[CH:5][NH:4][C:3]=1[CH2:7][CH2:8][C:9]([Cl:11])=[O:10]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
50 mg of palladium-on-charcoal at 10% are added to 500 mg (2.65 mmol) of 3-(5-methyl-3H-imidazol-4-yl)acrylic acid chloride in 10 ml of a 0.5N solution of sodium hydroxide. The reaction mixture is placed under 6 bar of hydrogen pressure and stirred at 80° C. for 72 hours. After having filtered off the catalyst through celite, the residue is acidified to pH 2 with hydrochloric acid, concentrated to dryness and taken up in ethanol. The insoluble material is filtered off and the filtrate is concentrated to dryness. 102 mg of 3-(5-methyl-3H-imidazol-4-yl)propanoic acid chloride are obtained in the form of a white powder with a yield of 16%.
후처리
- filtrationAfter having filtered off the catalyst through celite
- concentrationconcentrated to dryness
- filtrationThe insoluble material is filtered off
- concentrationthe filtrate is concentrated to dryness
출처 및 근거
- ORD 기록
- ord-22909198763949ee8182ca80a00743fa
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871187B2
반응 노트
불러오는 중…