Hydrochloric Acid → 3-But-2-ynyloxy-3-o-tolylazetidine hydrochloride

HRID 540432노트

반응식

HRID 540432 반응식
[CH2:1]([O:5][C:6]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])[CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7]1)[C:2]#[C:3][CH3:4].[ClH:24]>C(OCC)(=O)C>[ClH:24].[CH2:1]([O:5][C:6]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[CH3:23])[CH2:7][NH:8][CH2:9]1)[C:2]#[C:3][CH3:4]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 66988177Tert-butyl 3-but-2-ynyloxy-3-o-tolylazetidine-1-carboxylate

생성물 1

HCID 669881813-But-2-ynyloxy-3-o-tolylazetidine hydrochloride수율 96%

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

2.8 g (9 mmol) of tert-butyl 3-but-2-ynyloxy-3-o-tolyl-azetidine-1-carboxylate are solubilised in 40 ml (120 mmol) of a 3M solution of hydrochloric acid in ethyl acetate. After stirring for 1 hour 30 minutes at ambient temperature, the reaction medium is concentrated under vacuum. 2.2 g of 3-but-2-ynyloxy-3-o-tolylazetidine hydrochloride are obtained in the form of a beige solid with a yield of 96%.

후처리

  1. concentrationthe reaction medium is concentrated under vacuum

출처 및 근거

ORD 기록
ord-7c13f75f38be46da8434ad48515ef8b6
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871187B2

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