Hydrazine hydrate (1:1) → Oxolane-3-carbohydrazide
반응식
[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([O:8]C)=O)[CH2:2]1.O.[NH2:11][NH2:12]>>[O:1]1[CH2:5][CH2:4][CH:3]([C:6]([NH:11][NH2:12])=[O:8])[CH2:2]1참가 물질
3
실험 절차
Into around-bottom flask, was placed hydrazine hydrate (20 mL). To this was added methyl tetrahydrofuran-3-carboxylate (compound 38.1, 390 mg, 3.00 mmol, 1.00 equiv) dropwise with stirring. The resulting mixture was stirred at 50° C. in an oil bath. After 3 h, the reaction mixture was concentrated and dried under reduced pressure to yield 0.29 g (74%) of the title compound as a colorless oil.
후처리
- customInto around-bottom flask, was placed
- stirringThe resulting mixture was stirred at 50° C. in an oil bath
- concentrationthe reaction mixture was concentrated
- customdried under reduced pressure
출처 및 근거
- ORD 기록
- ord-38f8c1db6fa54ce0ab4ba1364e836a24
- 출처 데이터셋
- uspto-grants-2014_10
- 특허 번호
- US08871790B2
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