Hydrazine hydrate (1:1) → 2-(Tetrahydrofuran-2-yl)acetohydrazide

HRID 541260노트

반응식

HRID 541260 반응식
[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([O:9]CC)=O.[NH2:12][NH2:13].O>C(O)C>[O:1]1[CH2:5][CH2:4][CH2:3][CH:2]1[CH2:6][C:7]([NH:12][NH2:13])=[O:9]

참가 물질

4

반응물 2

HCID 24654Hydrazine hydrate (1:1)HCID 551345Ethyl Tetrahydrofuran-2-acetate

생성물 1

HCID 607781292-(Tetrahydrofuran-2-yl)acetohydrazide

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

To a round-bottom flask was added a solution of ethyl 2-(tetrahydrofuran-2-yl)acetate (2.00 g, 12.6 mmol, 1.00 equiv) in ethanol (20 mL). NH2NH2.H2O (1.27 g, 25.4 mmol, 2.00 equiv) was added to the reaction. The resulting solution was stirred overnight at 80° C. in an oil bath, then cooled to room temperature and concentrated in vacuo. This resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil.

후처리

  1. temperaturecooled to room temperature
  2. concentrationconcentrated in vacuo
  3. customThis resulted in 2.10 g (92%) of 2-(tetrahydrofuran-2-yl)acetohydrazide as a yellow oil

출처 및 근거

ORD 기록
ord-fd7e36a49ee94c47a871bf7e7cfaa5c4
출처 데이터셋
uspto-grants-2014_10
특허 번호
US08871790B2

반응 노트

불러오는 중…