Lithium Hydroxide → HCID 13708826, 화합물

HRID 54169노트

반응식

HRID 54169 반응식
[OH-].[Li+].[CH3:3][C:4](=[CH2:13])/[CH:5]=[CH:6]/[CH2:7][C:8]([O:10]CC)=[O:9]>CO.O1CCCC1.O>[CH3:13][C:4](=[CH2:3])/[CH:5]=[CH:6]/[CH2:7][C:8]([OH:10])=[O:9]

참가 물질

6

반응물 2

HCID 3939Lithium HydroxideHCID 14524662Ethyl trans-4-methyl-2,4-pentadienecarboxylate

생성물 1

HCID 13708826HCID 13708826, 화합물수율 76%

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매2회HCID 8028Tetrahydrofuran용매

실험 절차

2.5 g (0.1 mol) of lithium hydroxide are added at 0° C. to 10 g (0.07 mol) of ethyl trans-4-methyl-2,4-pentadienecarboxylate, dissolved in a solvent mixture of 75 ml of methanol, 17 ml of tetrahydrofuran and 2.5 ml of water, and the mixture is stirred for 20 hours at room temperature. After the mixture has been diluted with 200 ml of water, it is extracted once using diethyl ether, and a pH of 1 is established in the aqueous phase at 0° C. using concentrated hydrochloric acid. The mixture is extracted using diethyl ether, the combined organic phases are washed several times with water and saturated sodium chloride solution, and, after drying and concentrating, 6.1 g (76% of theory) of trans-4-methyl-2,4-pentadienecarboxylic acid are obtained. ##STR208##

후처리

  1. extractionis extracted once using diethyl ether
  2. customis established in the aqueous phase at 0° C.
  3. extractionThe mixture is extracted
  4. washthe combined organic phases are washed several times with water and saturated sodium chloride solution
  5. customafter drying
  6. concentrationconcentrating

출처 및 근거

ORD 기록
ord-299d8a018f6644f7be2076f3bd417fef
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622916

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