N-[(6-Methoxypyridin-2-yl)methyl]acetamide → (6-Methoxypyridin-2-yl)methanamine

HRID 542262노트

반응식

HRID 542262 반응식
C([NH:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1)(=O)C.Cl.NCC1C=CC=C(OC)N=1.Cl.NCC1NC(=O)C=CC=1>Cl>[NH2:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[N:7]=1

참가 물질

5

반응물 3

HCID 13882972N-[(6-Methoxypyridin-2-yl)methyl]acetamideHCID 13882974(6-Methoxypyridin-2-yl)methanamine hydrochlorideHCID 212435226-(Aminomethyl)pyridin-2(1H)-one hydrochloride

생성물 1

HCID 13882973(6-Methoxypyridin-2-yl)methanamine

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

The crude product, 2-acetamidomethyl-6-methoxypyridine from Example 1, was combined with 10 ml of 6N hydrochloric acid, and the resulting mixture was heated at its reflux temperature for about 16 hours. The mixture was evaporated to provide a tan solid residue. The product was determined by infrared and nuclear magnetic resonance spectral analyses to be a mixture of 2-aminomethyl-6-methoxypyridine hydrochloride and 6-aminomethyl-2(1H)-pyridone hydrochloride.

후처리

  1. temperaturethe resulting mixture was heated at its
  2. temperaturereflux temperature for about 16 hours
  3. customThe mixture was evaporated
  4. customto provide a tan solid residue

출처 및 근거

ORD 기록
ord-662e8a4a14424aeb82e9c2522529e6aa
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656285

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