Ethyl 3-amino-2-(p-chlorophenyl)propyl(diethoxymethyl)phosphinate → 3-Amino-2-(4-chlorophenyl)propylphosphonous acid hydrochloride

HRID 542314노트

반응식

HRID 542314 반응식
[NH2:1][CH2:2][CH:3]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)[CH2:4][P:5](C(OCC)OCC)(=[O:9])[O:6]CC>Cl>[ClH:23].[NH2:1][CH2:2][CH:3]([C:17]1[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=1)[CH2:4][P:5]([OH:9])[OH:6]

참가 물질

3

반응물 1

HCID 14362833Ethyl 3-amino-2-(p-chlorophenyl)propyl(diethoxymethyl)phosphinate

생성물 1

HCID 677836693-Amino-2-(4-chlorophenyl)propylphosphonous acid hydrochloride

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

A solution of 5.0 g of ethyl 3-amino-2-(4-chlorophenyl)propyl(diethoxymethyl)phosphinate in 60 ml of 36% aqueous hydrochloric acid is heated to reflux for a period of 1 hour. The reaction mixture is then allowed to cool to room temperature, concentrated under reduced pressure, and co-evaporated three times with 20 ml of water under reduced pressure to give 3-amino-2-(4-chlorophenyl)propylphosphonous acid hydrochloride, as a hygroscopic solid, 31P=+30.1 ppm (D2O).

후처리

  1. temperatureto reflux for a period of 1 hour
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-6722fd3fc370410c98eb50ea55dd7865
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04656298

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