참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Isopropanol | HCID 3776 | — |
| 반응물 | Benzenepropanoic acid, 4-nitro-beta-oxo-, ethyl ester | HCID 13281 | — |
| 반응물 | Ammonium Chloride | HCID 25517 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Acetic acid, (p-aminobenzoyl)-, ethyl ester (6CI,7CI) | HCID 3045879 | 83.1% |
반응 단계
A mixture of 224 g of reduced iron, 13.4 g of ammonium chloride, 1,000 ml of isopropyl alcohol, and 200 ml of water was prepared, and then 237 g of ethyl p-nitrobenzoylacetate was added thereto in small amounts at temperatures ranging between 50° and 70° C. They were reacted at 70° C. for 1 hour and then the reaction solution was filtered. Then, 1,000 ml of water was added to the filtrate and cooled to 5° C., and crystals precipitated were collected by filtration to yield 172 g of yellow ethyl p-aminobenzoylacetate crystals, m.p., 82°-4° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04657848 |
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| 출처 데이터셋 | uspto-grants-1987_04 |
|---|
| ORD ID | ord-e2635a4e17704d4890f22ca506076b41 |
|---|
| 출처 메모 | uspto-grants-1987_04 |
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