Acetic Anhydride → 5-(4-Acetamidophenyl)-3-methyl-2(1H)-pyrazinone
반응식
Br.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([CH3:16])[C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[C:17](OC(=O)C)(=[O:19])[CH3:18].C([O-])(=O)C.[Na+]>O>[C:17]([NH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[C:11]([CH3:16])[C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1)(=[O:19])[CH3:18]참가 물질
5
실험 절차
5-(4-Aminophenyl)-3-methyl-2(1H)-pyrazinone hydrobromide (1.0 g) in water (25 ml) was treated with acetic anhydride and sodium acetate in a similar manner to that described in Example 3. On recrystallisation from aqueous acetic acid the title compound (0.68 g) had m.p. >300° C.; δ(DMSO-d6) inter alia 2.08 (3H, s, CO--CH3), 2.39 (3H, d, 3---CH3), 10.0 (1H, s, NHCO); ν(Nujol mull) 1655 (C=O) cm-1.
후처리
- customOn recrystallisation from aqueous acetic acid the title compound (0.68 g)
출처 및 근거
- ORD 기록
- ord-595dc71e12104417ab19e7752504a160
- 출처 데이터셋
- uspto-grants-1987_04
- 특허 번호
- US04657906
반응 노트
불러오는 중…