Potassium cyanate → N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

HRID 542463

반응식

HRID 542463 반응식
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:5][CH:4]=1.[O-:16][C:17]#[N:18].[K+]>O.CN(C)C1C=CN=CC=1>[NH:2]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[N:10]=[CH:11][C:12](=[O:15])[NH:13][CH:14]=2)=[CH:7][CH:8]=1)[C:17]([NH2:18])=[O:16]

참가 물질

5

반응물 2

HCID 11378442Potassium cyanateHCID 197942325-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride

생성물 1

HCID 13853577N-[4-(5-Oxo-4,5-dihydropyrazin-2-yl)phenyl]urea

시약·촉매·용매 2

HCID 142844-(Dimethylamino)pyridine촉매HCID 962Water용매

실험 절차

5-(4-Aminophenyl)-2(1H)-pyrazinone hydrochloride (1.0 g) was dissolved in water (25 ml), to which solution potassium cyanate (0.4 g) and 4-dimethylaminopyridine (about 0.005 g) were added. The mixture was stirred at room temperature for 18 hours and the resulting suspended material collected by filtration. This was washed in hot dimethylformamide (30 ml), the insoluble material being collected and washed with water to afford the title compound, m.p. >300° C.; n.m.r. δ (DMSO-d6) 5.90 (s, 2H, --CONH2), 7.98, 8.10 (2d, 2H, pyridine H's); ν (liquid paraffin) 1710, 1665 cm-1.

후처리

  1. additionwere added
  2. filtrationcollected by filtration
  3. washThis was washed in hot dimethylformamide (30 ml)
  4. customthe insoluble material being collected
  5. washwashed with water

출처 및 근거

ORD 기록
ord-d5b7d78fdc07470980cafc7d40871642
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04657906

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