Iodoform → 1-Oxo-1-(4-chlorophenyl)-3-iodo-2-propene

HRID 54254

반응식

HRID 54254 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([CH:10]=O)=[O:9])=[CH:4][CH:3]=1.[CH:12](I)(I)[I:13]>O1CCCC1.[Cl-].[Cl-].[Cr+2]>[O:9]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=1)[CH:10]=[CH:12][I:13]

참가 물질

5

반응물 2

HCID 6374IodoformHCID 269588(4-Chlorophenyl)(oxo)acetaldehyde

생성물 1

HCID 543730961-Oxo-1-(4-chlorophenyl)-3-iodo-2-propene

시약·촉매·용매 2

HCID 10197677chromium(II) dichloride촉매HCID 8028Tetrahydrofuran용매

실험 절차

This compound is prepared in a manner analogous to that of Step C of Example 4, using 6.7 grams (0.04 mole) of 4-chlorophenylglyoxal (prepared by the method of Kornblum et al., JACS, (1957), 79, 6562), 29.5 grams (0.24 mole) of anhydrous chromium(II) dichloride, and 31.5 grams (0.08 mole) of iodoform in 600 mL of tetrahydrofuran, yielding 1-oxo-1-(4-chlorophenyl)-3-iodo-2-propene.

후처리

  1. customThis compound is prepared in a manner analogous to that of Step C of Example 4

출처 및 근거

ORD 기록
ord-96efb8b9fa07495b9c0fddd1bf2d549f
출처 데이터셋
uspto-grants-1997_04
특허 번호
US05622954

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