Hydrochloric Acid → (4,6-Dimethylpyrimidin-2-yl)cyanamide

HRID 542678

반응식

HRID 542678 반응식
[C:1]([NH:3][C:4]([NH2:6])=[NH:5])#[N:2].[CH3:7][C:8](=O)[CH2:9][C:10](=O)[CH3:11].Cl>O>[C:1]([NH:3][C:4]1[N:6]=[C:10]([CH3:11])[CH:9]=[C:8]([CH3:7])[N:5]=1)#[N:2]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 31261AcetylacetoneHCID 178418324HCID 178418324, 화합물

생성물 1

HCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide수율 70%

시약·촉매·용매 1

HCID 962Water용매

반응 조건

온도
120 °C

실험 절차

A mixture of 42 g (0.5 mol) of cyanoguanidine ("dicyanodiamide") and 50 g (0.5 mol) of pentane-2,4-dione ("acetylacetone") is heated to 120° C. for 15 hours. Thereafter, after the reaction mixture has been cooled, 500 ml of water are added and the solution is acidified with hydrochloric acid at 0° C. to 10° C. The product obtained in crystalline form in this procedure is isolated by being filtered off under suction. 51.8 g (70% of theory) of 2-cyanoamino-4,6-dimethyl-pyrimidine of melting point 205° C. are obtained.

후처리

  1. temperatureThereafter, after the reaction mixture has been cooled
  2. customThe product obtained in crystalline form in this procedure
  3. customis isolated
  4. filtrationby being filtered off under suction

출처 및 근거

ORD 기록
ord-f14adb14524b4b93912b188aaac680b6
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659364

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