Ethanol → 2-(3-Bromo-5-methoxyphenyl)acetic acid

HRID 542739노트

반응식

HRID 542739 반응식
[Br:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[C:6](CC#N)[CH:7]=1.[OH-:13].[Na+].[CH2:15]([OH:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[C:6]([CH2:16][C:15]([OH:13])=[O:17])[CH:7]=1

참가 물질

4

반응물 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 212429652-(3-Bromo-5-methoxyphenyl)acetonitrile

생성물 1

HCID 212429042-(3-Bromo-5-methoxyphenyl)acetic acid

실험 절차

A mixture of 5-bromo-3-methoxyphenylacetonitrile (22.6 g, 0.1 m) and 10% aqueous sodium hydroxide (300 ml) in ethanol (225 ml) is heated to 95° for 18 hours. The mixture is concentrated in vacuo, acidified with 10% hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxyphenylacetic acid.

후처리

  1. temperatureis heated to 95° for 18 hours
  2. concentrationThe mixture is concentrated in vacuo
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. washis washed
  6. dry with materialdried with sodium sulfate
  7. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-806a1132f0874682accb093aca335200
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04659706

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