Sodium borohydride → HCID 13247648, 화합물

HRID 543328노트

반응식

HRID 543328 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([C:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)=[O:7])=[CH:4][CH:3]=1.[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:20]=[CH:19][C:5]([CH:6]([C:8]2[C:9]([N:14]3[CH:18]=[CH:17][N:16]=[CH:15]3)=[N:10][CH:11]=[CH:12][CH:13]=2)[OH:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 2

HCID 4311764Sodium borohydrideHCID 13247647HCID 13247647, 화합물

생성물 1

HCID 13247648HCID 13247648, 화합물수율 89%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매2회

실험 절차

To a solution of 4.8 g of 3-(4-chlorobenzoyl)-2-(1-imidazolyl)pyridine in 35 ml of ethanol and 5 ml of water is added 0.64 g of sodium borohydride. After the mixture is stirred at room temperature for an hour, the reaction mixture is poured into water and extracted with chloroform. The chloroform is distilled off and the residue is recrystallized from toluene to give 4.3 g of α-(4-chlorophenyl)-2-(1-imidazolyl)-3-pyridinemethanol as white crystals, melting at 133°-134° C.

후처리

  1. extractionextracted with chloroform
  2. distillationThe chloroform is distilled off
  3. customthe residue is recrystallized from toluene

출처 및 근거

ORD 기록
ord-c1ee3f8b47da4c8783eacc8df334087e
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661603

반응 노트

불러오는 중…