Methyl iodide → 4-tert-Butyl-2-(methanesulfonyl)-1-methoxybenzene

HRID 543373노트

반응식

HRID 543373 반응식
[CH3:1][C:2]([C:5]1[CH:6]=[C:7]([S:13]([OH:15])=[O:14])[C:8]([O:11][CH3:12])=[CH:9][CH:10]=1)([CH3:4])[CH3:3].[CH2:16](N(CC)CC)C.IC>CC(C)=O>[CH3:4][C:2]([C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13]([CH3:16])(=[O:15])=[O:14])[CH:6]=1)([CH3:1])[CH3:3]

참가 물질

5

반응물 3

HCID 6328Methyl iodideHCID 8471TriethylamineHCID 13210234HCID 13210234, 화합물

생성물 1

HCID 127215654-tert-Butyl-2-(methanesulfonyl)-1-methoxybenzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

17.4 g (0.076 mol) of 3-(1,1-dimethylethyl)-6-methoxybenzenesulfinic acid are suspended in 120 ml of acetone, and 13.3 ml (0.095 mol) of triethylamine and 8.5 ml (0.12 mol) of iodomethane are added. The mixture is stirred at room temperature for 2 hours and then poured onto ice-water. The precipitate which separates out is filtered off with suction and recrystallized from N-butanol.

후처리

  1. additionpoured onto ice-water
  2. filtrationThe precipitate which separates out is filtered off with suction
  3. customrecrystallized from N-butanol

출처 및 근거

ORD 기록
ord-7fa0fd4a64fa42e292b09e0f1c4eef59
출처 데이터셋
uspto-grants-1987_04
특허 번호
US04661636

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