Acetic Anhydride → Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

반응식

F[C:2](F)(F)[C:3]([NH:5][C:6]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14](C(=O)C(F)(F)F)=[CH:13][CH:12]=2)[N:7]=1)=[O:4].C(OC(=O)C)(=O)C>>[C:11]1([N:8]2[CH2:9][CH2:10][C:6]([NH:5][C:3](=[O:4])[CH3:2])=[N:7]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

반응물 2

HCID 7918Acetic Anhydride

HCID 15580703HCID 15580703, 화합물

생성물 1

HCID 793093Acetamide, N-(4,5-dihydro-1-phenyl-1H-pyrazol-3-yl)-

실험 절차

A 10.0 g. amount of 3-amino-1-phenyl-2-pyrazoline (prepared in Example 8) and 10.0 ml. of acetic anhydride are mixed together and allowed to stand at room temperature for one hour. The resulting solid is collected, dissolved in dichloromethane and passed through a short column of a hydrous magnesium silicate. The effluent is heated and hexane is added to crystallize 1.2 g. of the desired product as yellow prisms, m.p. 190°-191° C.

후처리

customThe resulting solid is collected
dissolutiondissolved in dichloromethane
temperatureThe effluent is heated
additionhexane is added
customto crystallize 1.2 g

출처 및 근거

ORD 기록: ord-fec04c99ecac418591f684f81c1828a2
출처 데이터셋: uspto-grants-1984_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04447442

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