Hydrazine hydrate (1:1) → 4-(3-Methoxypropyl)-3-thiosemicarbazide
반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[S:10])SC.O.[NH2:12][NH2:13]>C(O)C>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][NH:6][C:7](=[S:10])[NH:12][NH2:13]참가 물질
4
반응 조건
- 온도
- 70 °C
실험 절차
A solution of methyl N-(3-methoxypropyl)dithiocarbamate (100.2 g) in ethanol (300 ml) was added dropwise at 3° C. over 30 minutes to a solution of hydrazine hydrate (28 g) in ethanol (200 ml). The mixture was stirred for 4.5 hours at 70° C. The reaction mixture was concentrated and to the residue were added water and diethyl ether. The diethyl ether extract was dried over magnesium sulfate and evaporated in vacuo to give pinkish oil of 4-(3-methoxypropyl)thiosemicarbazide (89.9 g).
후처리
- concentrationThe reaction mixture was concentrated and to the residue
- additionwere added water and diethyl ether
- extractionThe diethyl ether extract
- dry with materialwas dried over magnesium sulfate
- customevaporated in vacuo
출처 및 근거
- ORD 기록
- ord-2f3947d111d94fc5ac6e8d0a683d498a
- 출처 데이터셋
- uspto-grants-1984_05
- 특허 번호
- US04447429
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