5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine → 5-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride

HRID 5439

반응식

HRID 5439 반응식
[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3].[ClH:18].CO>CO>[ClH:18].[CH3:1][S:2]([NH:5][CH2:6][CH2:7][S:8][C:9]1[N:14]2[CH:15]=[CH:16][N:17]=[C:13]2[CH:12]=[CH:11][CH:10]=1)(=[O:4])=[O:3]

참가 물질

4

반응물 2

HCID 152293635-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridineHCID 21893726Hydrochloride methanol

생성물 1

HCID 200866555-[2-(Methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine.hydrochloride수율 89.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A suspension of 5-[2-(methylsulfonylamino)ethylthio]imidazo[1,2-a]pyridine (543 g, 2 mmoles) in methanol (20 ml) was treated with hydrogen chloride-methanol. After the solvent was distilled off, the residue was crystallized from chloroform ether. Then, the crystals thus obtained were washed with ether and dried to obtain 550 mg of the desired product (89.3%, colorless crystals).

후처리

  1. distillationAfter the solvent was distilled off
  2. customthe residue was crystallized from chloroform ether
  3. customThen, the crystals thus obtained
  4. washwere washed with ether
  5. customdried

출처 및 근거

ORD 기록
ord-90e3544a7e8d48009be88fd306d4e8e7
출처 데이터셋
uspto-grants-1993_09
특허 번호
US05244908

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