Methyl iodide → Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

HRID 544276노트

반응식

HRID 544276 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N:12]([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1.[CH3:19][I:20]>CC(C)=O>[I-:20].[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:9]23[CH2:17][CH2:16][CH2:15][CH2:14][CH:13]2[N+:12]([CH3:19])([CH3:18])[CH2:11][CH2:10]3)[CH:6]=[CH:7][CH:8]=1

참가 물질

4

반응물 2

HCID 6328Methyl iodideHCID 12838428Hexahydro-3a-(m-methoxyphenyl)-1-methylindoline

생성물 1

HCID 12838431Hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4.6 g of hexahydro-3a-(m-methoxyphenyl)-1-methylindoline are dissolved in 100 ml of acetone, and the solution is treated with 10 ml of methyl iodide. The mixture is boiled at reflux for 10 hours. Thereafter, the solvent is removed by distillation, and the residue is recrystallized from acetone. The hexahydro-3a-(m-methoxyphenyl)-1,1-dimethyl-indolinium iodide obtained melts at 195°-196° C.

후처리

  1. temperatureat reflux for 10 hours
  2. customThereafter, the solvent is removed by distillation
  3. customthe residue is recrystallized from acetone

출처 및 근거

ORD 기록
ord-68b8bf7b9436479db3eb52cde6c63fcf
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04448991

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