4-Chloro-3-methylphenol → 1-Chloro-4-methoxy-2-methylbenzene

HRID 544335

반응식

HRID 544335 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][C:3]=1[CH3:9].[C:10](=O)([O-])[O-].[K+].[K+].CI>CC(C)=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:10])=[CH:4][C:3]=1[CH3:9]

참가 물질

5

반응물 3

HCID 17324-Chloro-3-methylphenolHCID 6328Methyl iodideHCID 11430Potassium Carbonate

생성물 1

HCID 4581561-Chloro-4-methoxy-2-methylbenzene

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

4-Chloro-3-methylphenol (28.5 g., 0.2 mole) was dissolved in 400 ml. of acetone. Potassium carbonate (33.1 g., 0.24 mole) and then methyl iodide (34.1 g., 0.24 mole) were added and the mixture stirred for 16 hours at room temperature. The reaction mixture was filtered and the filtrate evaporated to an oil containing solids. This residue was distributed between methylene chloride and water. The organic layer was separated, washed in sequence with two portions of 1N sodium hydroxide, two portions of water and one portion of brine, dried over anhydrous magnesium sulfate and concentrated to yield 4-chloro-3-methylanisole as an oil [24.6 g., 86%, pnmr/CDCl3 /delta. 2.3 (s, 3H), 3.7 (s, 3H) 6.9 (m, 3H)].

후처리

  1. filtrationThe reaction mixture was filtered
  2. customthe filtrate evaporated to an oil
  3. additioncontaining solids
  4. customThe organic layer was separated
  5. washwashed in sequence with two portions of 1N sodium hydroxide, two portions of water and one portion of brine
  6. dry with materialdried over anhydrous magnesium sulfate
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-289984adbf8d495fb4a0e22340a457c2
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04448971

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