Iodoethane → 2-Ethoxynaphthalene-1-carbaldehyde

HRID 544337

반응식

HRID 544337 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13].I[CH2:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[CH2:15]([O:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]=1[CH:12]=[O:13])[CH3:16]

참가 물질

5

반응물 3

HCID 6340IodoethaneHCID 11430Potassium CarbonateHCID 128192-Hydroxy-1-naphthaldehyde

생성물 1

HCID 880992-Ethoxynaphthalene-1-carbaldehyde

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

2-Hydroxy-1-naphthaldehyde (10 g., 0.058 mole) was combined with acetone (120 ml.), iodoethane (9.9 g., 0.063 mole) and anhydrous potassium carbonate (8.0 g., 0.058 mole) and the mixture heated to reflux for 48 hours. The reaction mixture was cooled to room temperature, filtered and filtrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether afforded purified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.).

후처리

  1. temperaturethe mixture heated
  2. temperatureto reflux for 48 hours
  3. filtrationfiltered
  4. customfiltrate evaporated to solids (9.0 g.) Recrystallization from isopropyl ether
  5. customafforded
  6. custompurified 2-ethoxy-1-naphthaldehyde in two crops (4 5 g. and 0.5 g., m.p. 106°-109° C.)

출처 및 근거

ORD 기록
ord-690cd4173f8f47649acec3860e20b21f
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04448971

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