Phosphorus oxychloride → 3-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

HRID 544458노트

반응식

HRID 544458 반응식
[F:1][C:2]1[CH:21]=[CH:20][CH:19]=[CH:18][C:3]=1[CH2:4][O:5][C:6]1[C:7]2[N:8]([C:12]([CH2:16]O)=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.P(Cl)(Cl)([Cl:24])=O>>[Cl:24][CH2:16][C:12]1[N:8]2[CH:9]=[CH:10][CH:11]=[C:6]([O:5][CH2:4][C:3]3[CH:18]=[CH:19][CH:20]=[CH:21][C:2]=3[F:1])[C:7]2=[N:14][C:13]=1[CH3:15]

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 20458963HCID 20458963, 화합물

생성물 1

HCID 204589533-Chloromethyl-8-(2-fluorobenzyloxy)-2-methylimidazo[1,2-a]pyridine

실험 절차

A mixture of 8-(2-fluorobenzyloxy)3-hydroxymethyl-2-methyl-imidazo[1,2-a]pyridine from Example 5 (1 g) and phosphorylchloride (15 ml) was heated under reflux for1 hr. Excess phosphorylchloride was distilled off in vacuo, the residue dissolved in hot ethanolic HCL and the mixture filtered to give the title compound as the hydrochloride salt.

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for1 hr
  3. distillationExcess phosphorylchloride was distilled off in vacuo
  4. dissolutionthe residue dissolved in hot ethanolic HCL
  5. filtrationthe mixture filtered

출처 및 근거

ORD 기록
ord-897ce9cb6cf94f23b5992075724e1d19
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450164

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