Phosphorus oxychloride → 8-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine

HRID 544459노트

반응식

HRID 544459 반응식
[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:15]=[C:16]([CH2:18]O)[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.P(Cl)(Cl)([Cl:22])=O>>[CH2:1]([O:8][C:9]1[C:10]2[N:11]([CH:15]=[C:16]([CH2:18][Cl:22])[N:17]=2)[CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 24813Phosphorus oxychlorideHCID 20458946[8-(Benzyloxy)imidazo[1,2-a]pyridin-2-yl]methanol

생성물 1

HCID 204590038-(Benzyloxy)-2-(chloromethyl)imidazo[1,2-a]pyridine

실험 절차

A mixture of 8-benzyloxy-2-hydroxymethylimidazo[1,2-a]pyridine (2 g) and phosphorylchloride (10 ml) was heated on a steam bath for 1 hr. Excess phosphoryl chloride was distilled off in vacuo, the solid residue triturated with acetonitrile and the mixture filtered to give the title product as the hydrochloride salt.

후처리

  1. temperaturewas heated on a steam bath for 1 hr
  2. distillationExcess phosphoryl chloride was distilled off in vacuo
  3. customthe solid residue triturated with acetonitrile
  4. filtrationthe mixture filtered

출처 및 근거

ORD 기록
ord-ae148568f6294f2fbb8f6fff8a9ff9cb
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450164

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