Sodium borohydride → 2-Methylimidazo[1,2-a]pyridine-8-methanol

HRID 544474노트

반응식

HRID 544474 반응식
[CH3:1][C:2]1[N:3]=[C:4]2[C:9]([CH:10]=[O:11])=[CH:8][CH:7]=[CH:6][N:5]2[CH:12]=1.[BH4-].[Na+]>C(O)(C)C>[CH3:1][C:2]1[N:3]=[C:4]2[C:9]([CH2:10][OH:11])=[CH:8][CH:7]=[CH:6][N:5]2[CH:12]=1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydride2회HCID 139002412-Methylimidazo[1,2-a]pyridine-8-carbaldehyde

생성물 1

HCID 139003302-Methylimidazo[1,2-a]pyridine-8-methanol

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a stirred suspension of 56.8 g (0.36 mol) 2-methyl-8-formylimidazo[1,2-a]pyridine in 400 ml isopropanol at 0°is added in portions 8 g (0.21 mol) sodium borohydride. The reaction mixture is stirred at room temperature for an additional 2 hours. The excess sodium borohydride is decomposed by the addition of distilled waterand the solution concentrated under reduced pressure at 50° C. The residue is dissolved in water and extracted with chloroform. The chloroform extracts are combined and dried over anhydrous sodium sulfate. Following filtration, the chloroform is removed under reduced pressure to give 2-methyl-8-hydroxymethylimidazo[1,2-a]pyridine.

후처리

  1. concentrationconcentrated under reduced pressure at 50° C
  2. dissolutionThe residue is dissolved in water
  3. extractionextracted with chloroform
  4. dry with materialdried over anhydrous sodium sulfate
  5. filtrationfiltration
  6. customthe chloroform is removed under reduced pressure

출처 및 근거

ORD 기록
ord-0cd4031f60504719a0755472e7bc360a
출처 데이터셋
uspto-grants-1984_05
특허 번호
US04450164

반응 노트

불러오는 중…